In the ever-evolving world of aesthetic treatments, it can be challenging to choose the most suitable treatment for your skin type and the results you’d like to achieve. Two popular injection-based options are Profhilo and Profhilo Structura, both designed to improve skin quality, but with distinct differences in their application and benefits.
They’re both excellent choices for combating the signs of ageing. The choice between the two depends on your skin’s needs, the areas you want to treat, and how much structural support your skin requires. They can also be used in combination to achieve a more comprehensive facial rejuvenation.
Combining a Profhilo treatment and Botox might just be your ticket to more youthful-looking skin. These two treatments are not only safe to use in conjunction but also complement each other well. Profhilo hydrates and tightens your skin from within while Botox smooths out wrinkles by relaxing your facial muscles. The result? A double whammy against signs of ageing that leaves you with a refreshed and rejuvenated appearance.
Profhilo is an injectable skin remodelling treatment designed to hydrate and rejuvenate the skin deeply. Unlike traditional fillers, which add volume and reshape the face, Profhilo primarily works by increasing the skin’s elasticity, firmness, and hydration.

Profhilo Structura is an advanced version of the original Profhilo treatment, designed to target more specific areas of concern where volume loss and skin sagging are more pronounced. Like Profhilo, it uses hyaluronic acid, but with a unique formulation that provides additional structural support to the skin.
Choose Profhilo Structura if needing targeted support for areas of significant volume loss, skin sagging, or more advanced ageing concerns. It offers a subtle lifting and contouring effect with a longer-lasting result.
Consulting with a qualified aesthetic practitioner is the best way to determine which treatment will give you the results you desire. At Eterno Aesthetics Sheffield, we offer a no-obligation consultation that can be redeemed towards our Profhilo treatments and more if you decide you want to proceed.
30 minutes.
Moderate. Numbing cream for Profhilo is optional.
24 hours.
6 months. Results are visible 8 weeks after the treatment.
Maintenance treatment advised every 6 months.

Looking for a non-surgical solution to tired, dull, or ageing skin? Profhilo is an injectable designed to target skin laxity, improve skin quality, and restore youthful radiance. Unlike traditional fillers, Profhilo stimulates collagen and elastin, helping to smooth fine lines, soften deep wrinkles, and enhance facial contours for a refreshed, lifted appearance.

Profhilo helps to minimise the signs of skin laxity by reversing the breakdown of collagen and elastin in our skin. These natural skin proteins are key structural components to keep our skin firm and taut, but they slowly deplete through the ageing process, causing our skin to loosen and sag. Profhilo combats this process by rebooting the production of these proteins in deeper levels of our skin.

With age, our skin loses its elasticity, resulting in sagging and wrinkles. Profhilo treatment works by promoting the production of collagen and elastin—two crucial proteins that help maintain skin structure and firmness. By enhancing skin elasticity, Profhilo can help lift and tighten the skin, providing a more youthful contour to your face.

Profhilo’s high HA content hydrates the skin from the inside out through the absorption of water (up to 1000 times its own weight in fact!). This intense hydration from within makes the skin look plump and glowing and improves skin texture over time.
Before any skin treatment, a consultation is essential. This dedicated time allows for an in-depth conversation around your desired results, an assessment of your skin, and a tailored recommendation on the most suitable method for your skin type and lifestyle.
Everything from maintenance to aftercare is discussed in detail. It’s a considered, personalised approach that ensures results are not only beautiful, but lasting.
We take a fully refundable deposit of £50 for all our consultations. Your deposit can be refunded in the clinic or redeemed against our treatments or products purchased after the consultation.
EXCELLENT Based on 117 reviews Posted on Google Francine BentleyTrustindex verifies that the original source of the review is Google. I highly recommend Eterno Aesthetics, who are a member of Save Face, the only government approved register for non-surgical cosmetic treatments. I have been visiting the clinic for several years and honestly I would not go anywhere else. The whole team are really professional, friendly and welcoming, they really make you feel at ease. The clinic itself is always spotless, comfortable and well designed. Hannah is amazing, she’s a registered nurse and is so knowledgeable, patient and up to date with all the latest techniques and treatments the beauty industry has to offer. I completely trust her advice and always leave feeling great!Posted on Google Sophie JaneTrustindex verifies that the original source of the review is Google. I've been going to Eterno for 7 years and wouldn't go anywhere else. The whole team are amazing, so friendly, and the clinic is always spotless. Hannah takes the time to talk through everything with you, and strikes the perfect balance between professional and personable. As a clinic, they are often taking on further training and making sure they are ahead of the curve with the newest, most effective treatments. 11/10 - no notes!Posted on Google louise heardTrustindex verifies that the original source of the review is Google. Thank you ladies, had the Morpheus 8 for the first time which in all honesty is not painless but with a bit of laughter and some positive words I made it through!. I can't wait to see the resultsPosted on Google Dawn ParkinTrustindex verifies that the original source of the review is Google. Always a pleasure visiting Hannah and all the girls! Very friendly and helpful. I trust Hannah fully to make whatever I have look very natural! I trust her implicitly and wouldn’t go anywhere else. 😃Posted on Google Kerry ThompsonTrustindex verifies that the original source of the review is Google. Another lovely visit today, had my final polynucleotides which have made such a difference i would definitely recommend!!!Posted on Google Nicky ElliottTrustindex verifies that the original source of the review is Google. Had Skinveve Juverderm performed by the lovely Hannah. No pain no swelling no downtime! Hannah explained everything to me. Can’t wait to see the results. Such a fab team of girls xxPosted on Google inga chihaiaTrustindex verifies that the original source of the review is Google. I recently visited Eterno Aesthetic Clinic for an exosome treatment as a model, and as always, it was an absolutely wonderful experience! The entire process was smooth, comfortable, and completely free of any discomfort or downtime — I was able to go about my day right after the session. The staff at Eterno are consistently professional, knowledgeable, and incredibly friendly, which makes every visit such a pleasant experience. I’ve been using their services for over 5 years now, and they never fail to deliver top-quality care and results. I truly appreciate their dedication to excellence and genuine care for their clients. I would highly recommend Eterno Aesthetic Clinic to anyone looking for safe, effective, and advanced aesthetic treatments!Posted on Google Amanda StrongTrustindex verifies that the original source of the review is Google. I’ve been going to Hannah at Eterno now for a few years. They’re outstanding! They are professional, efficient, friendly and welcoming and I feel really looked after in a safe hygienic environment. Calming atmosphere and very knowledgeable. A lovely place to come and leave looking fresh and natural. Thank you xPosted on Google Laura BurstonTrustindex verifies that the original source of the review is Google. Everyone there is so friendly, instantly putting you at ease. I've been going there for a good while now and I'd never go anywhere else. The place also smells amazing!Posted on Google mason eadesTrustindex verifies that the original source of the review is Google. Very professional skin clinic. Calm environment and makes you feel relaxed ! Also, Hannah is very good at what she does. Thank you so much